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Image Search Results
Journal: bioRxiv
Article Title: Redundancy in the central tachykinin systems safeguards puberty onset and fertility
doi: 10.1101/443333
Figure Lengend Snippet: Repeated stimulation (every 12 h) of WT female mice with GR64349 (NK2R-A, 3 nmol/100ul/ip) or vehicle (0.9% NaCl/100ul/ip) from p23 to p32 (n≥6 per group). (A) Progression of VO, (B) mean postnatal day of VO and (C) BW the day of 50% of the control animals displayed VO. (D) Uterine weight, (E) ovarian weight and (F) serum LH levels at p32. Statistical analysis was performed using a 2-tailed t test (*p < 0.05; ***p< .001).
Article Snippet: The agonists of NK1R (GR73632),
Techniques:
Journal: bioRxiv
Article Title: Redundancy in the central tachykinin systems safeguards puberty onset and fertility
doi: 10.1101/443333
Figure Lengend Snippet: (A) LH release before (basal), 25 and 60 min after the icv injection of NK2R-Ag, senktide or the co-administration of both (600 pmol/5ul/icv) in WT OVX+E 2 females (n ≥ 5 per group). *p<0.05 vs. corresponding basal levels. (2 Way ANOVA followed by Tukey post hoc test). (B) LH levels before (basal) SB222200 (7 nmol5ul/icv) administration and at 25 and 60 minutes after injection of NK2R-Ag (600 pmol/5ul/icv), senktide (600 pmol/5ul/icv) or vehicle (0.9% NaCl/5ul/icv) in WT OVX+E 2 females (n ≥ 4 per group). *p<0.05 vs. corresponding basal levels. # p<0.05 vs. corresponding control mice at the same time point (2 Way ANOVA followed by Tukey post hoc test). (C) LH before (Basal) and at 25 and 60 minutes after injection of NK2R-Ag (600 pmol/5ul/icv) in OVX+E 2 WT and Tac2 KO females (n≥5 per group). *p<0.05 vs. corresponding basal levels (2 Way ANOVA followed by Tukey post hoc test).
Article Snippet: The agonists of NK1R (GR73632),
Techniques: Injection
Journal: bioRxiv
Article Title: Redundancy in the central tachykinin systems safeguards puberty onset and fertility
doi: 10.1101/443333
Figure Lengend Snippet: (A) LH release before (basal), 25 and 60 min after icv injection of NK2R-Ag, senktide or the co-administration of both (600 pmol/5ul/icv) in WT OVX females (n≥5 per group). *p<0.05 vs. corresponding basal levels; # p<0.05 vs. NK2R-Ag at the same time point (2 Way ANOVA followed by Tukey post hoc test). (B) LH levels before (basal) SB222200 (7 nmol5ul/icv) injection and at 25 and 60 minutes after injection of NK2R-Ag (600 pmol/5ul/icv), senktide (600 pmol/5ul/icv) or vehicle (0.9% NaCl/5ul/icv) in WT OVX females (n≥5 per group). *p<0.05 vs. corresponding basal levels (2 Way ANOVA followed by Tukey post hoc test). C) LH levels before (basal), 25 and 60 minutes after injection of naloxone (5mg/kg/100ul/ip) or vehicle (0.9% NaCl/100ul/ip) in WT OVX females (n≥5 per group). *p<0.05 vs. corresponding basal levels (2 Way ANOVA followed by Tukey post hoc test). (D) LH levels before (basal) and at 25 and 60 minutes after injection of NK2R-Ag (600 pmol/5ul/icv) in OVX WT and OVX Tac2 KO females (n≥5 per group). *p<0.05 vs. corresponding basal levels (2 Way ANOVA followed by Tukey post hoc test). # p<0.05; ## p<0.01 vs. corresponding WT levels (2 Way ANOVA followed by Tukey post hoc test). E) LH levels before (basal) and at 25 and 60 minutes after injection of NK1R-Ag (600 pmol/5ul/icv), NK2R-Ag (600 pmol/5ul/icv) or vehicle (0.9% NaCl/5ul/icv) in WT OVX females (n≥5 per group). Groups 2 – 4 were pre-injected 30 min before the basal sample with NK1R-Antg (2 nmol/5ul/icv). *p<0.05 vs. corresponding basal levels (2 Way ANOVA followed by Tukey post hoc test); # p<0.05 vs. NK1R-Antg + vehicle injected mice levels. (F) LH release before (basal) NK1R-Antg (2 nmol/5ul/icv) injection and at 25 and 60 minutes after injection of NK2R-Ag (600 pmol/5ul/icv) in Tac2 KO OVX females (n≥5 per group). *p<0.05 vs. corresponding basal levels (2 Way ANOVA followed by Tukey post hoc test); # p<0.05 vs. vehicle injected mice.
Article Snippet: The agonists of NK1R (GR73632),
Techniques: Injection